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There is high contamination risk of the end-product with potentially dangerous leaches, in addition to possible contaminants originated from the biological source [20]

Moreover, the interpretation of biomarker responses is complicated by the poor bioavailability and limited bloodbrain barrier penetration of many phytochemicals

Additionally, an abundance of tumour infiltrating T-Lymphocytes (TILs) and the so-called Crohns-like reaction with prominent aggregates at the periphery of the tumour, suggesting a local inflammatory response, have been reported 10

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